Dr. Carlo Rinaldi Receives Co-Funded AANEM Foundation/MDA Grant for Research on Spinal and Bulbar Muscular Atrophy
Carlo Rinaldi, MD, PhD, has been selected as the recipient of a development grant co-funded by the AANEM Foundation and the Muscular Dystrophy Association (MDA). Dr. Rinaldi, who works as an Associate Professor in the Department of Physiology, Anatomy and Genetics in the Division of Medical Sciences at the University of Oxford in the United Kingdom, will be using this funding to increase understanding of the pathophysiology of spinal and bulbar muscular atrophy (SBMA). SBMA is a neuromuscular disorder characterized by the degeneration of lower motor neurons and primary muscle atrophy. Dr. Rinaldi’s ultimate goal is to develop effective therapeutic treatments for this yet incurable condition.
Dr. Rinaldi’s research objective is to characterize the role
of the androgen receptor (AR) isoform 2 on AR biology and its impact on SBMA
toxicity. His central hypothesis is that AR45 is a key regulator of AR activity
and represents a promising therapeutic target for SBMA.
“There is currently no treatment available for SBMA,”
explained Dr. Rinaldi. “This research work has the potential to shed new light
on the role of the AR isoforms in both health and disease, advance
understanding of the mechanisms of pathogenesis in SBMA, and provide a new
therapeutic target in close relationship with the disease-causing
mutation.”
“Dr. Rinaldi has the strong support of the Neuroscience community
in Oxford to pursue his research into the mechanisms of motor neuron
degeneration in SBMA,” noted Kevin Talbot, MB, PhD, FRCP, Head of the Division
of Clinical Neurology and Professor of Motor Neuron Biology and Consultant
Neurologist at John Radcliffe Hospital in Oxford. “This is a neglected area and
he is in an excellent position to be a leader in this field, both within Europe
and worldwide.” …
No comments:
Post a Comment
Please feel free to comment. By taking a moment to share your thoughts you add much to these articles. The articles then become more than just something I said or believe. In addition, by adding a comment, you might just be helping the next reader by sharing your opinion, experience, or a helpful tip. You can comment below or by sending me an email. I look forward to hearing from you.