Creatine Monohydrate Trial

I found this report on a trial conducted in 2014 and 15. I searched for the final analysis and can’t locate it. Perhaps you will have better luck than me. If so, let me know.

Treatment with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Yasuhiro Hijikata, MD, PhD, Masahisa Katsuno, MD, PhD, Keisuke Suzuki, MD, PhD, Atsushi Hashizume, MD, PhD, Amane Araki, MD, PhD, Shinichiro Yamada, MD, PhD, Tomonori Inagaki, MD, Daisuke Ito, MD, Akihiro Hirakawa, PhD, Fumie Kinoshita, MSc, Masahiko Gosho, PhD, and Gen Sobue, MD, PhD

Background

Although spinal and bulbar muscular atrophy (SBMA) has been classified as a motor neuron disease, several reports have indicated the primary involvement of skeletal muscle in the pathogenesis of this devastating disease. Recent studies reported decreased intramuscular creatine levels in skeletal muscles in both patients with SBMA and transgenic mouse models of SBMA, which appears to contribute to muscle weakness.

Objective

The present study aimed to examine the efficacy and safety of oral creatine supplementation to improve motor function in patients with SBMA.

Results

Participant enrollment in the trial started from June 2014 and follow-up was completed in July 2015. The study is currently being analyzed.